Altogen Labs is a Good Laboratory Practice (GLP)-compliant laboratory providing innovative biotechnology research services for pharmaceutical, biotechnology, and academic institutions worldwide. Our services include laboratory pre-clinical research, development of stable RNAi cell lines, IC50 pharmacology/toxicology studies, xenograft animal models, liposome encapsulation (proteins, DNA, siRNA), RNA interference (RNAi) and gene silencing (siRNA / shRNA design, qRT-PCR mRNA amplification and gene knockdown), ELISA and cell-based assay development (fluorescent-based, ATP, cell viability, proliferation, cell cycle), pyrosequencing services, teratoma formation and analysis, bioremediation, tissue-targeted in vivo delivery services, siRNA encapsulation, tissue culture services, transient and stable transfection (protein overexpression), cloning, and assay development.

Company scientists bring years of experience and expertise, including pre-clinical studies, cell and molecular biology, siRNA transfection and RNAi research. Altogen Labs provides a wide range of GLP-compliant contract research organization services to meet clients' unique needs, including A-to-Z stable cell line development and cell banking services. Technical support and quality control teams ensure and support the company’s high-quality products and services. Company scientists have also applied advanced biotechnological techniques to develop new bioremediation products and services.

Bioremediation is one of the company's focus areas in biotechnology. Bioremediation is a process that uses microorganisms, fungi, green plants, and their enzymes to restore the environment to its original state after contamination. Bioremediation has been used for centuries after corruption of soil by salt, sewage, and other contaminants, particularly in agriculture. Bioremediation of soil or water following contamination by crude oil is performed by a variety of bacteria that feed on hydrocarbons, breaking down the petroleum molecules into less harmful substances. These naturally occurring bacteria can potentially be isolated and expanded to help remediate oil spills, an approach well accepted by nature with minimal threat to marine ecosystems.

Recently, Altogen Labs successfully isolated oil-degrading microbes from polluted soil near Galveston, Texas. These microbes were shown in laboratory tests to be effective in bioremediation of petroleum-saturated earth. A method was developed to cultivate oil-degrading bacteria specific to the site of a particular spill, microbes that act on the hydrocarbon molecules present at the polluted site. The bacteria are grown in large volumes in an aqueous solution, from which the water is eventually evaporated to yield a high concentration of bacteria in dry form and low volume. The product is very stable and the dry bacteria can be activated by simply re-introducing a water-based solution. The growth conditions for these natural bacterial strains were optimized for effective oil degradation in Texas soil. Optimization included considering variables in temperature, soil conditions, and oil composition such that these microbes could be used to remediate contaminated soil on-site when reintroduced in large numbers.

This technology offers great potential for cleaning up contaminated soil due to rupture of underground storage tanks, pesticides, percolation of contaminated surface water, oil and fuel dumping, leaching of wastes from landfills, and direct discharge of industrial wastes to the soil. Read more about Bioremediation, Oil-degrading Bacteria, Bioremediation Products and Services

"Very impressed with the rapid turnaround and overall quality of service. Thank you!"                        -Dr.Michael Kruer, Sanford College of Medicine, University of South Dakota, Sioux Falls.