Altogen Labs extensive biotechnology and pharmacology research services include the following:
- PRE-CLINICAL RESEARCH SERVICES
- Pharmacology and toxicology testing: IC50 for Tumor Cell Lines
- Xenograft Animal Service: Immunocompromised NOD/SCID Mice
- Therapeutic RNAi development: targeted siRNA, qPCR assays
- Liposome Encapsulation services: siRNA, miRNA, DNA, proteins
- ELISA and Cell-Based Assay Development (Cell Cycle, Viability)
- Apoptosis Assay: Caspase-3 and Caspase-7 Cell Line Screen
- RNAi Consulting Services: technology delevopment & evaluation
- GENERATION OF STABLE CELL LINES
- CELL BANKING
- RNA INTERFERENCE (RNAi) SERVICES
- In vivo siRNA delivery and tissue-targeting
- siRNA Transfection and RNAi Cell-based Library Screening
- Generation of Tet-inducible RNAi gene knockdown cell lines
- RNAi screen pathway analysis: siRNA and microRNA library
- RNAi manufacturing and CRO services
- PCR Cloning: shRNA-encoding vector construction
- In Vivo Stable siRNA and microRNA - Chemical modification
- Quantitation sh/siRNA-induced knockdown by qRT-PCR and WB
- Reporter gene assays and Stable RNAi cell line development
- Genome-wide siRNA and microRNA high-throughput screens
- Stable RNAi Cell Line Generation: Stable Gene Knockdown
- siRNA liposome encapsulation service
- Transient (siRNA) and stable (shRNA) transfection services
- BIOLOGY LABORATORY CRO SERVICES
- BIOREMEDIATION
- BACTERIA ID 16S SEQUENCING
Bioremediation Products and Services
Bioremediation: Oil-degrading Bacteria Products and Services
A number of commercial bioremediation products were recently developed. Most bioremediation products are nutrient-based additives or non-specific microbial cultures which lack efficiency in field tests and applications. Bioremediation companies are currently working to develop a superior microbiology systems to improve microbial culture effectiveness and profit in the oil clean-up business.
Oil-degrading bacteria, which occur naturally in the environment, are of particular interest to bioremediation companies and scientists because of the positive impact of these bacteria on remediating oil spills in the planet’s oceans.
Contamination of the earth’s oceans by oil can be both man-made and naturally occurring. Each year, some 250 million liters of petroleum enter the marine environment from natural seepage. These leaks from the ocean floor contain aromatic compounds that are toxic to most life forms and can cause major ecological insults. However, despite its toxicity to most organisms, a considerable percentage of petroleum entering marine systems is eliminated by the hydrocarbon-degrading activities of various microbial communities, in particular, by a recently discovered group of microbes known as hydrocarbonoclastic bacteria (HCB). Of this group, the bacterium Alcanivorax borkumensis was the first HCB to have its genome sequenced by scientists and is now the subject of study by researchers around the world.
Alkanes, which are the saturated hydrocarbons upon which A. borkumensis feeds, are the petroleum degradation products that arise from the process of microbial catabolism; these molecules are the principle focus of the articles presented below.
see also: Oil-degrading Bacteria | Bioremediation Products and Services | Bioremediation: Oil-degrading bacteria